Tag Archive : Lift Caps

Appetite out of control? Lift may just be the answer!

Once you have made up your mind to lose weight, you should make that a goal and go into it with a positive attitude. The Life Priority Lift or Lift Caps formula can help you think like a winner, and envision yourself the way you want to look and feel. It’s not what you do occasionally that counts, it’s what you do consistently on a daily basis.

Appetite out of control? Lift or Lift Caps with L-Phenylalanine may be the answer!

If you’re really serious about controlling your appetite and are tired of battling your cravings and added pounds, here’s a safe way to control your appetite and finally get your weight under control! The Lift formulation with the amino acid L-Phenylalanine-a nutritional supplement that helps curb your appetite and elevates your mood.

So what is Phenylalanine?

Phenylalanine is an essential amino acid that acts as an appetite suppressant by promoting the release of intestinal hormone-cholecystokinin-which signals the brain to feel satisfied after eating. The amino acid L-Phenylalanine
is found in a variety of foods, including almonds, avocados, bananas, brown rice, cheese, corn, eggs, fish, lima beans, peanuts, pumpkin seeds, sesame seeds, and soy products. Problem is, you’d have to eat lots of extra calories in order to get an effective amount.

No matter how hard you try to avoid calorie-laden carbs, let’s face it-after a lifetime of bad eating habits, it’s tough. And even if you’ve switched over to eating fruits and air-popped popcorn, the carbohydrates quickly add up, which can contribute to a rapid increase in blood sugar levels-which the body responds to by raising levels of insulin. Inevitably weight gain, occurs around the middle, with a craving for sweets, breads, or other carbohydrates shortly after a meal-which only adds to the vicious cycle of trying to get off the carbohydrate merry-go-round.

If you take Lift or Lift Caps with L- Phenylalanine, 30 minutes to one hour before eating a meal, you’ll notice that you’ll might feel more alert and feel full faster- so you don’t fill up on extra calories that you don’t need! And not only that, you’ll stay full longer so you don’t get that late afternoon or after-dinner snack attack. Lift is a  great support for those of who need more motivation and energy to exercise too! Lift can help support a more productive and positive exercise regiment. Before you know it, those extra pounds you’ve been carrying around will start to melt away-safely and effortlessly.

 So Stay Positive with Lift, and Exercise!

 Caution: Phenylalanine should not be taken by pregnant women, or those who suffer from high blood pressure, diabetes, phenylketonuria, skin cancer, or anxiety attacks. It should not be used it taking MAO inhibitor drugs, commonly prescribed for depression.

LIVE LONG & PROSPER!

FDA Disclaimer

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.

Information provided for educational purposes only. *These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.

*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.

*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

The information provided is for educational purposes only. Recommendations are not intended to replace the advice of your doctor or competent health care professional. REV. 9/16

 

Energy Drinks and Mental Fitness

Healthy Energy Drinks and Mental Fitness

Life Priority teamed up with life extension scientists, Durk Pearson & Sandy Shaw® to market and develop a full line of healthy products called Designer Foods to improve and enhance your cognitive function, which spans not only memory, but attention, learning, problem solving, decision making, and reasoning.

Each new day presents challenges that, if not met and overcome, may leave you less fit mentally to control your life . . . to achieve your financial goals . . . to set the stage for pursuing your personal happiness.

By starting each day with a cool, refreshing glass of delicious LIFT™ (or LIFT Caps™) or Mind™ or Muscle Memory™), you can embrace a lifelong “Mental Fitness” program.

Life Priority healthy drink mixes, many of which are healthy energy drink mixes. These include the LIFT™ family mentioned above, all of which employ the amino acid phenylalanine, a precursor to an important memory molecule, noradrenaline, and your brain’s version of adrenaline. They also include the necessary enzyme cofactors vitamin B6, vitamin C, copper, and folic acid, along with natural flavors.

These formulations are based on the nutrient choline, which is the important memory nutrient involved in concentration and focus.* As we age, choline becomes less bioavailable, with serious consequences for memory function.

The “Mental Fitness” drinks are great-tasting, natural, fruit-flavored citrus cooler containing choline and essential nutrient cofactors plus the important amino acid taurine. Use Mind to help preserve and protect your memory function.*

Supplements for Memory “Loss”

Over time, the effects of too little sleep, aging, and the stress of a busy life can impair both your cognitive and memory functions. It may seem as if your memory has been “lost.” While many try to combat these effects with stimulants like caffeine, these only provide a temporary lift, and come with a host of unwanted side effects. Instead of masking the symptoms, why not improve the underlying problems instead? Try our Productive Sleep drink with choline.

Our formulas are carefully tested to ensure that they are safe and meet your needs. Often taking cues from historical findings, our scientists use their knowledge of the human body to create formulas based on scientific studies. They give real results.

Instead of settling for poorly designed energy drinks or caffeine pills that provide only a short burst of energy followed by a mental crash, consider products that have been developed using real science. Other sources can leave you feeling jittery, and carry the threat of weight gain from all the extra sugar and calories these drinks usually contain. If you rely on products like caffeine, you may also experience the symptoms of addiction. With Life Priority products, these are concerns you no longer have to consider. We carefully test all products to ensure that as long as the proper dosage recommendations are followed, you will notice no negative side effects from their use.

Drink Mixes

Nutrient Drink Mixes are a delicious way to supplement your diet with additional vitamins, minerals and amino acids necessary for enhanced cognitive, physical and sexual function. When mixed with water or your favorite beverage, they’re a convenient and efficient way to fuel your body, helping you feel and perform at your very best.

Life Priority   offers a wide variety of formulations for increased energy, mood and sleep enhancement, improved sexual function, weight loss, HGH release, and “Smart Nutrients” for cognitive enhancement and creative mental energy. Just choose the formula (or two) that’s right for you. We think you’ll be pleasantly surprised at how delicious, convenient and effective they are. At Life Priority, we offer a variety of “smart nutrients” from several different formulators. When mixed with water or your favorite beverage, they’re a convenient and efficient way to fuel your body, helping you feel and perform at your very best.

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.

*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.

*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

Mental Fitness is a Life Priority!

Mental Fitness is a Life Priority!

As we age and encounter multiple stressors and responsibilities, our minds become pulled countless directions and we can see the negative effects. Sometimes we forget things, can’t focus or be as sharp as we once were and this can hurt our daily lives. To overcome these deficiencies, we reach for caffeine or other artificial sources in an attempt to regain our former mental capacities, but things like caffeine don’t solve the problem. Artificial boosters can only keep you “up” for so long before you come crashing back down, and they have other harmful side effects. So instead of providing your mind and body with a temporary solution, chooses to help correct the whole problem and create a healthier you.

Life Priority has paired with scientists Durk Pearson & Sandy Shaw® and their expertise since 1994 to establish a line of supplements specifically designed to help improve and develop your brain and all of its cognitive faculties. These products were created after countless hours of research and testing. We only use the safest and highest quality ingredients based on Durk and Sandy’s recommendations. With so much care directed toward providing a quality product, our supplements are designed to deliver real results.

Lift and Lift Caps were created to help provide you with some energy when you’re feeling like you’re on empty. Lift™ is great because it’s the natural way to help increase energy. It helps stimulate your mind and your body using your own faculties so you don’t experience a caffeine crash later. In addition to helping with your energy and focus, Lift™ can also help curb your appetite and thus help you lose weight. Two other great products are Mind™ and Muscle Memory™.  They can help improve your memory, concentration and physical ability to function. All of these supplements can help you create a healthier mind and body for the future, instead of just for a few hours or a day.

 

Too often in today’s world, people look for the quick fix. Our lives are filled with so many responsibilities and obstacles that finding solutions to problems instead of masking them is challenging. Caffeine and energy drinks can only do so much or so long, and they can lead to negative side effects in some cases like weight gain. Instead of reaching for these quick fixes, make the decision to create a healthier you with a healthier lifestyle using natural supplements. With Life Priority, your health is our only concern and our line of carefully tested products is designed to help suit your needs and help you become healthier.

To Your Mental Health!

Life Priority Inc. www.lifepriority.com 800-787-5438

Information for educational purposes only. Not intended to diagnose, treat or cure any medical condition.

B Proactive With Your Brain Health-Vitamin B Is the Key

As we age, our brains accrue more and more stress. The rigors of life can slow our minds and thinking ability down while also causing problems with memory. Yes, our age plays a role on cognitive function, but we could also be deficient in essential vitamins, like Vitamin B.

A lack of Vitamin B in your diet can come at a hefty price. Symptoms include moodiness, trouble sleeping, a mental haze, and lack of energy. None of these are good, and can disrupt anyone’s day or even way of life.  The scary thing is that deficiencies in Vitamin B are not just limited to the elderly. Anyone can be deficient at any age. Vitamin B can be found in leafy greens, legumes and fruits.

Life Priority Lift PowderOf course incorporating more of those Vitamin B sufficient foods in your diet are important, but sometimes even that isn’t enough. Adding supplements to your diet can really help ensure you’re getting enough of the right vitamins and minerals for your body to be healthy.

Lift and Mind are two Life Priority products which include Vitamin B in their formulas. Both are designed with the intention to help give your brain and mind a mental boost and eliminate mental fatigue. Lift might MIND Brain Health Supplementhelp you feel less tired and more alert and energetic for the day ahead. Mind on the other hand, could possibly help with your memory, thinking and analyzing skills. These products just might be able to help you feel 20 years younger mentally and more rejuvenated. If you have any of the symptoms listed above, see if Lift and Mind can help your brain start feeling younger today.

 

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.
*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.
*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

Dietitian Carrie Mark-Why I started using Life Priority supplements..

As a dietitian I advise that you try and get all the nutrients you need through food, but realistically getting 100% of all required nutrients on a daily basis through food can be a challenge; since everyone’s lives are so busy, and hectic, and processed food is always just around the corner to choose. That’s why I started using Life Priority supplements. These products are not only made with the highest quality of ingredients but they have been proven to provide the nutrients they say they will.

Life Priority Lift Caps

One of my favorites is the Lift Caps. The Lift Caps not only provide you with all your B vitamins but they provide many other essential vitamins as well that give me the energy boost I need to get through my days of working, working out, and parenting. When I first received the sample I wasn’t sure about the product and I thought it would be much like other supplements that I have taken, and I wouldn’t notice a difference at all by taking them. But, I was quickly proven wrong with just one use.

I take the Lift Caps every day and every day I am amazed at the amount of energy they provide me. Before I started taking the Lift Caps I would catch myself not wanting to work on projects for work, work out, and I dreaded the after school routine of homework, lessons, practice and dinner. Now I don’t dread it at all, as I have the energy and mental stamina to get me from work, to the gym, to the after school routine with my kids.

I would recommend Lift Caps to anyone who is feeling like they just don’t have the energy. You will be surprised and amazed at the results and how much better you will feel after just one day of taking them.

 

Carrie Mark, MA, RDN, LD
Acquisition Director
NCES, Inc   800-445-5653yourwellnessspot.comwww.http://ncescatalog.com
www.lifepriority.com  800-787-5438
Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities. Information provided for educational purposes only. *These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.
*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.
*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

 

Life Priority: A Teacher’s Assistant To Help Eliminate Mental Fatigue

A teacher’s testimonial from valued Life Priority customer, Leigh Sanders. “I love teaching, and the best teacher’s aide I’ve ever had are my Life Priority Supplements.”

My husband and I have been using Life Priority supplements for over 10 years.  We were small business owners for 15 years and now Stan works as a consultant and I am an elementary school teacher, which is very exhausting.  Don’t believe it when your hear someone say teachers only work 8-4, 5 days a week, 9 months out of the year because they are very wrong!  Most of us put in anywhere from 50-60 hours per week August through May (not to mention the planning we do during the summer.)

I keep a mixture of LIFT and Muscle Memory at school and drink it Life Priority Lift Powderthroughout the day, especially when I need that afternoon pick-me-up and helps me eliminate my mental fatigue.  Instead of reaching for a soda or caffeinated beverage, I drink my LIFT/MM mixture or take the LIFT caps.


I play tennis, bike, and walk for exercise, so my other favorite supplement is the Joint Decision.  Joint Decision keeps my knees and neck more flexible.  Stan travels quite a bit so he keeps a bottle of the LIFT Caps in his brief case since those are easy to travel with.

Four years ago, my youngest son Austin broke his foot, which required a plate and six screws for it to heal properly.  I loaded him up on 3-Way Calcium and Joint Decision and he recovered well ahead of schedule.  He is currently a baseball player in college and uses LIFT, Muscle Memory, and Joint Decision to keep him focused and healthy.

Leigh S.  Olathe, KS

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.
*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.
*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

Testimonial: Dave Wickersham- Former MLB Pitcher

A great friend, and former MLB pitcher, Dave Wickersham is a valued Life Priority customer.

In a 10-season career, Wickersham posted a 68–57 record with 638 strikeouts and a 3.66 ERA in 1123 innings, including 29 complete games, five shutouts and 19 saves. Notably, Wickersham has been one of four players (fellow pitchers Aurelio Monteagudo, Moe Drabowsky and Ken Sanders being the other three) to play for both Kansas City-based major league teams, the Athletics and Royals. (sourced from Baseball Reference)

Wickersham also pitched for the Pittsburgh Pirates and Kansas City Royals.

Dave Wickersham signed his autograph with a Bible verse, Colossians 3:17: “And whatever you do, in word or deed, do everything in the name of the Lord Jesus, giving thanks to God the Father through him.”

Recently, I asked Dave a few baseball questions and his use of dietary supplements.

The following is a Q & A with Dave:

Greg:  What is a good memory about playing in MLB?

Dave: Being able to play with and against the best players in the world for 10 years.

Greg:  What was your biggest personal thrill in your Royals career?

Dave:  Coming in relief against the Yanks with the bases loaded and none out and getting out of it with no runs scored.

Greg:  Would you have done anything differently during your career?

Dave:  I can’t think of anything that I would have done differently accept trying for a bigger contract after winning 19 games!

Greg:  Why do you use dietary supplements?

Dave:  Because they have helped me live a better quality of life.

Greg:  Why do you use products from Life Priority (www.lifepriority.com)?

Dave: Because of the Pryor’s’ enthusiasm for the products. They have never led me astray.

Thanks for the memories Dave!  Let’s play two!

Dave Wickersham Uses JD, Lifeguard COQ10, Lift Caps

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.

*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.

*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

Greg Pryor: Fighting the Stress of Post Season Baseball

KC Royals 1985 World Series Win

KC Royals 1985 World Series Win

After I attended my first MLB game in Cleveland, Ohio as a 7-year-old, I became “addicted” to baseball.  Fortunately I was able to spend 16 seasons as a professional player (5 seasons for the Kansas City Royals).  I have experienced the depths of stressful feelings that baseball can create, on and off the field.  Last season, all KC Royals fans were treated to one of the best postseason runs in baseball history.  I noticed a resurgence of incredible love for Royals baseball from thousands of “veteran” fans and new ones.

We were constantly on the edge of our seats during the month of September and October as we lost work time and sleep!  Some of us forgot what day of the week it was! From the glorious night of last season’s Wild Card game versus the Oakland A’s to the last out of the World Series….WE FELT STRESSED!

The ’15 Royals team has been so much fun to watch from spring training to the inevitable day we clinched our first American League Central Division title since 1985! We are thinking ahead of who our opponents might be in the Division playoffs, and, hopefully, the American League championship and World Series game. Again, it is STRESS time for many Royals fans!

As a co-owner of a health and nutrition company for the past 20 years (lifepriority.com), this is a great time to inform you about how stress affects us and offer some information that might help increase your natural defense systems to deal with the stress in our lives, especially all Royals fans!

Stress is the body’s natural response to threatening situations, and it affects everyone. Stress can be good, like buying a

brainnew car, or bad, like running up credit cards. Either way, your body and mind react to such situations with a heightened state of readiness, which is called the “fight or flight” response. This reaction causes your brain to make hormones including adrenaline and cortisol.

Adrenaline gives you more energy by increasing your heart rate and blood pressure.  Cortisol increases the amount of glucose in your blood and impairs bodily functions that might be harmful in a fight or flight situation, such as digestion and reproduction. This can help you perform well on a test or at a sporting event, but it can also distract you, keep you up at night, and make you lose your appetite.

Stress becomes chronic when your body does not shut off its stress response, so you are always in a heightened state of readiness.  This affects your immune system and can lead to mental and physical health problems.

One of the ways that you can defend yourself is to make sure that you provide your body with stress-reducing nutrients through your diet. To ensure that your diet provides you with enough of those nutrients, you should consider supplementing your diet with a potent, high-quality multi-vitamin with adequate amounts of B vitamins, vitamin C, vitamin D3, and omega-3 fatty acid. Life Priority offers the following products that allow you to touch all of your nutritional bases so put them into your daily nutritional “lineup”: One Per Meal Lifeguard, Sunlife, Omega-3 Priority, Vita C2, Lift and Mind.  Read about these great products and other Life Priority products at www.lifepriority.com today!

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.
*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.
*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

Nutritional “Lineup”To Combat Stress of PostSeason Baseball!

 

Greg Little League Baseball

Me- kneeling behind the baseball!

After I attended my first MLB game in Cleveland, Ohio as a 7-year-old, I became “addicted” to baseball.  Fortunately, I was able to become a pro baseball player for 16 seasons. I played in the majors for the Texas Rangers, Chicago White Sox and the Kansas City Royals. I experienced the depths of stressful feelings that baseball can create, on and off the field.

Baseball fans are constantly on the edge of their seats during the months of September and October as they lose sleep over each crucial loss. Sometimes I even forget what day of the week it is! From the Wild Card games to the last out of the World Series….WE FEEL STRESSED!

As a co-owner of a health and nutrition company for the past 20 years (lifepriority.com), this is a great time to inform you about how stress affects us and offer some information that might help increase your natural defense systems to deal with the stress in our lives, especially all baseball fans!

Stress is the body’s natural response to threatening situations, and it affects everyone. Stress can be good, like buying a

brainnew car, or bad, like running up credit cards. Either way, your body and mind react to such situations with a heightened state of readiness, which is called the “fight or flight” response. This reaction causes your brain to make hormones including adrenaline and cortisol.

Adrenaline gives you more energy by increasing your heart rate and blood pressure.  Cortisol increases the amount of glucose in your blood and impairs bodily functions that might be harmful in a fight or flight situation, such as digestion and reproduction. This can help you perform well on a test or at a sporting event, but it can also distract you, keep you up at night, and make you lose your appetite.

Stress becomes chronic when your body does not shut off its stress response, so you are always in a heightened state of readiness.  This affects your immune system and can lead to mental and physical health problems.

One of the ways that you can defend yourself is to make sure that you provide your body with stress-reducing nutrients through your diet. To ensure that your diet provides you with enough of those nutrients, you should consider supplementing your diet with a potent, high-quality multi-vitamin with adequate amounts of B vitamins, vitamin C, vitamin D3, and omega-3 fatty acids. Life Priority offers the following products that might allow you to touch all of your nutritional bases so put them into your daily nutritional “lineup”: One Per Meal Lifeguard, Sunlife, Omega-3 Priority, Vita C2, Lift and Mind.

Read about these great products and other Life Priority products at www.lifepriority.com today!

To Your Health a Life Priority-Sincerely, Greg Pryor

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities
*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.
*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

Time Is On My Side….Yes, It Is

The Durk Pearson & Sandy Shaw®life-extension-book
Life Extension NewsTM
Volume 20 No. 2 • March 2017

TIME IS ON MY SIDE … YES, IT IS

by Sandy Shaw

The difference between drug use and addiction or eating and metabolic diseases is time. The amount of time we take a potentially addictive drug determines whether we become addicted; this is also true for eating—eating for only a limited period of time can prevent the development of metabolic diseases, such as diabetes type 2 (Hatori, 2012).

An example of how time can determine the result of eating: a recent study of male mice fed a high fat diet found that restricting feeding to only eight hours a day WITHOUT REDUCING CALORIES as compared to being free to eat at any time prevented metabolic diseases (such as obesity, hyperinsulinemia, fatty liver, and inflammation).

Dopamine is required for the estimation of time by the internal clock. “Interval timing, the ability to discriminate durations in the seconds-to-minutes range, is a form of temporal cognition that requires an optimal level of dopaminergic function in cortico-striatal circuits in order to control time sharing and regulate clock speed.” A time interval is initiated by cortical oscillators in the ventral tegmental area of the brain by a burst of dopamine accompanied by a burst of theta power, which act as the “start gun” (Kononowicz, 2015).

The internal clock is critically controlled by dopaminergic agonists and antagonists. Dopamine agonists such as cocaine and methamphetamine (“speed”) have been shown to increase the speed of the internal clock, while dopamine antagonists such as haloperidol and raclopride have been shown to decrease the speed of the internal clock (Cheng, 2007).

In another study (Sysoeva, 2010), researchers found that there is an association of serotonin (5-HT) related genes with time perception. In their experiment, forty-four Russian Caucasian males (right handed and with a mean age of 22) compared two durations (they had to indicate which of them was shorter) on a computer monitor. “Many studies have reported an association between duration representation parameters and personality, specifically impulsivity and psychoticism.” Unsurprisingly, other studies have found psilocybin, a 5-HT (serotonin) receptor agonist, to affect time perception (Sysoeva, 2010).

“Despite the evidence … suggesting the centrality of DAergic [dopaminergic] modulation in mediating the drug-induced euphoria and timing distortions reported here, this explanation is likely an oversimplification of the processes underlying the individual differences observed in this study. Neuromodulators such as serotonin, GABA, glutamate, and norepinephrine, have also been found to influence time perception and to interact with DA [dopamine] in complex ways (Lake, 2013).” Another neuro­transmitter with important effects on drug addiction and incentive-motivated behaviors is acetylcholine (Lester, 2010).

WHEN TIME SLOWS DOWN

You’ve all experienced it—the times when sudden danger appears, such as your car is about to hit a tree, and time slows release of adrenaline as you rapidly close in on the tree. As explained above, stimulants such as methamphetamine cause a large release of dopamine and this increases the speed of the internal clock. A hypothesis proposes that the reason this feels like time is slowing down is that your brain sees time as the amount of information it processes—the more bits of information is counted as a longer period of time compared to the usual number of bits you experience as “regular” time (Eagleman, 2005).

In a similar fashion, seeing an event in “slow motion” causes observers to believe that more time had passed than actually had (Caruso, 2016). Thus, time is under­estimated.

A very recent paper (Soares, 2016) reported how mice judged the passage of time (judging the duration of intervals). Using a pharmacogenetic method to suppress dopaminergic neuronal activity in the substantia nigra pars compacta, they found that “[s]ituations in which DAergic [dopaminergic] activity is elevated naturally, such as states of high approach motivation, response uncertainty, or cognitive engagement are associated with underestimation of time. Conversely, situations that decrease DAergic activity, such as when fearful or aversive stimuli are presented are associated with overestimation of time.”

The bottom line: “… pleasurable events boost dopamine release, which should cause your internal clock to run faster … so that short intervals seem longer than they are (Simen, 2016).”

FLOW

Time stands still if you go fast enough.

—Stephen F. Kaufman, marial arts professional (Ch.
19 in his book “The Way Of The Modern Warrior”)

Who hasn’t experienced FLOW? The trick is being able to produce it when you want it.

Flow is often described as a state of effortless concentration so deep that people who experience it lose their sense of time. It gives you a sense of acting without conscious awareness, of time slowing down, of perceiving yourself to be moving through a dreamlike state.*
Szxycj at English Wikipedia We knew a highly skilled champion racecar driver (Mickey Thompson) who told us that using a Lift formulation of ours had, in a very long off-road auto race (the BAJA 1000, when it was 1000 miles rather than 1000 kilometers) resulted in time slowing down, with everything happening exactly right and without any conscious effort on his part. He said that it felt like the flow he had experienced in his best races.
The formulation that Mickey took was one of those we designed for our own use that contains the amino acid phenylalanine. Phenylalanine can be converted into tyrosine (which is then converted to dopamine) but also into phenethylamine (also called phenylethylamine), a neuromodulator that provides mental energy like caffeine, but also acts as a stimulus barrier (helps to filter out distractions). Phenylalanine is found in our Lift formulas.

Caffeine provides mental energy in a different way than phenylalanine (see above). Phenylalanine is a natural compound that increases dopamine (via conversion to tyrosine) but, unlike caffeine (a xenobiotic), it does not mimic the effects of amphetamine and cocaine, like caffeine can do at 4-5 times the average human consumption of coffee. At high doses (300-800 mg), caffeine can increase feelings of anxiety, nervousness, and insomnia. Caffeine does NOT have addictive potential at the usual level of human consumption (50-300 mg or 1-3 cups of coffee), but induces feelings of well-being, alertness, energy, and ability to concentrate. Most of the effects of caffeine are reported to take place at adenosine receptors, where caffeine is an inhibitor (Nehlig, 2000). There are other changes, though, which include a 26-30% increase in the densities of cortical muscarinic and nicotinic cholinergic receptors; the evidence supports significant alterations in adenosine, adrenergic, serotonergic cholinergic, and GABAergic systems (Shi, 1993).

NUTRIENTS THAT MODIFY THE SPEED OF THE INTERNAL CLOCK

The amino acid tyrosine is precursor to dopamine, that is, converted to dopamine. (The amino acid phenylalanine is converted to tyrosine, so it is an indirect precursor to dopamine.) As noted above, dopamine agonists increase the speed of the internal clock (Cheng, 2007; Meck, 1987). This feels like time is slowing down. (Interestingly, “flow” is a process in which time does feel as though it is slowing down.)

WHEN PLEASURE BECOMES A HABIT

In the scientific literature, addiction is often called habit formation. Habit formation differs immensely from goal-directed activity. Where goal-directed activity is influenced by the outcome of performing an action, addictive activity is not—a negative outcome does not influence it.** If an action is habitual, “then devaluation should have no effect on performance, since habits are elicited by antecedent stimuli which are not affected by devaluation. “… habitual behavior is not controlled by the action-outcome contingency … (Yu. 2009)”

This can be seen in lever pressing by experimental animals. “At first lever pressing is goal-directed and sensitive to manipulation like outcome devaluation. Under certain conditions, it can become more habitual and impervious to changes in the value of the outcome … Studies in flies, mice, rats, horses, monkeys, and humans have shown some version of this transition from more flexible and goal-directed behavior to inflexible and habitual behavior.” (Yu, 2009)

It was purely the feeling that had captivated me, made me sacrifice everything to it, gladly, joyfully. It was a seashell’s pristine whisper in my ear, warm sun rising in my heart, fireflies winking in the nerves.

—Will Bohnaker, Haunts of The Aardwolf, on the allure of caffeine

EATING: DELAY DISCOUNTING

A recent paper (Johnson, 2010) points to a proposal that “deficits in reward processing may be an important risk factor for the development of obesity, and that obese individuals may compulsively consume palatable food to compensate for reward hyposensitivity.” This is another way of saying “self-medication.”

The dopaminergic nervous system is critically involved in the perception of pleasure from eating and sex. In fact, “the degree of pleasure from eating correlates with [the] amount of dopamine release (Stice, 2008).” The chronic overeating of high fat and high sugar foods causes a decrease in the sensitivity of dopaminergic neurons as a result of downregulation (reduced signaling). Animal studies have found similar effects from overeating and also in response to chronic drug use. Both overeating and the use of addictive drugs cause downregulation of dopamine D2 receptors and decreased D2 sensitivity.

A deficiency in the release of dopamine in the dorsal striatum may also be seen in individuals with a certain variant (allele) of the D2 dopaminergic receptor gene, the Taq1A A1 allele; it is interesting to note that this allele is involved in impulsivity, which is defined as “the relative preference for a smaller reward, sooner in time, compared to a larger reward, later in time … (Eisenberg, 2007)” This is called delay discounting—and “non-human research suggests that corticostriatal mesolimic substrates mediate delay discounting performance and that dopamine is the critical neurotransmitter involved.” (Eisenberg, 2007) The famous marshmallow experiments were a particularly notable example of delay discounting.

MONOAMINE OXIDASE A (MAOA) AND IMPULSIVITY

Monoamine oxidase A (MAOA) is a gene importantly affecting impulsivity. “… the risk imparted by the specific genetic variation studied here [MAOA] contributes to the impulsive dimension of this complex behavior [aggression].” The monoamine oxidase A (MAOA) gene, is of two types—MAOA-L (the low expression variant) and MAOA-H (the high expression variant). MAOA-L is associated with an increased risk of violent behavior. “Arguably, the clearest link between genetic variation and aggression exists for monoamine oxidase A (MAO-A) … a key enzyme in the catabolism [breakdown] of monoamines, especially serotonin.” The enzyme catabolizes dopamine, serotonin, and norepinephrine, reducing their availability for signaling at neuronal synapses (Meyer-Lindenberg, 2006). Hence, reduced catabolism, as with the MAOA-L variant, will not decrease the availability of dopamine, serotonin, and norepinephrine for signaling as much as the MAOA-H variant.

Goal-directed dimensions of aggression have been associated with psychopathy, often accompanied by diminished empathy and remorse. In their study (Meyer-Lindenberg, 2006), the researchers found that “men, but not women, carrying the low-expression MAOA genotype showed increased [emotional] reactivity during retrieval of negatively valenced emotional material.” Interestingly, men have only one allele (copy) of the MAOA gene, whereas women have two. The reason for this is that men have only one X chromosome (where the MAOA gene is located), while (of course) women have two. Interestingly, estrogens have been shown to affect the expression of MAOA in the brain (Meyer-Lindenberg, 2006).

Higher dominance has been associated with the low expression variant of MAOA (MAOA-L) and aggression in males in studies of primates.

SEROTONIN AND IMPULSIVITY

As noted above, serotonin deficiency is associated with impulsive behavior. This can be corrected by taking tryptophan, the amino acid that is converted to 5-hydroxytryptophan by the enzyme tryptophan hydroxylase and then to serotonin. However, some individuals are unable to make this conversion in sufficient amounts because their version of the enzyme lacks adequate potency. A way to overcome this is to take 5-HTP (5-hydroxytryptophan), which bypasses the need for tryptophan hydroxylase. We suggest taking 25 to 50 mg of 5-HTP at bedtime. We get ours from our Serene Tranquility with 5-HTP.™

DELAY DISCOUNTING MEETS THE GRASSHOPPER AND THE ANT
The Ant and the Grasshopper Another experiment on delay discounting (like the marshmallow experiments) was performed in human subjects, who made a series of choices between early and delayed monetary rewards while they were examined by fMRI (functional magnetic resonance imaging) (McClure, 2004). As a result, the researchers developed a hypothesis for how the brain decides between the early and later rewards. “… we hypothesize that short-run impatience is driven by the limbic system, which responds preferentially to immediate rewards and is less sensitive to the value of future rewards, whereas long-run patience is mediated by the lateral prefrontal cortex and associated structures, which are able to evaluate trade-offs between abstract rewards, including rewards in the more distant future.”
They allude to the metaphor of the grasshopper and the ant. The grasshopper spends its time enjoying the present and ignoring what may come later, while the patient ant works diligently preparing for the future. The authors call delay discounting the competition between the “impetuous limbic grasshopper” and the “provident prefrontal ant.” (McClure, 2004).”

In sum, the researchers suggest that “human behavior is often governed by a competition between lower level, automatic processes that may reflect evolutionary adaptations in particular environments, and the more recently evolved, uniquely human capacity for abstract, domain-general reasoning and future planning.”

Another hypothesis on the neuro­chemistry of delay discounting (Kravitz, 2012) proposes that addiction (in which the future consequences of using drugs are ignored) depends upon the interaction between dopamine D1 receptors and dopamine D2 receptors: dopamine D2 receptors counteract dopamine D1 receptors in determining the probability of performing a future action. The D1 receptors induce persistent reinforcement, while the D2 receptors induce transient “punishment” (negative signaling) for the performance of a future action. “In contrast, depression is marked by impaired reinforcement from positive stimuli and heightened punishment from negative stimuli (Kravitz, 2012).”

SPEAKING OF ANTS …

Yes, speaking of ants, a recent paper appeared in the “Research Highlights” section of the 29 Sept. 2016 Nature which reported that ants can get hooked on morphine. The ants were given access to sugar water laced with morphine. Then, over the course of several days, the amount of sugar in the water was reduced while the morphine content was increased, until eventually there was NO sugar in the water, only morphine. The ants, given a choice between sugar water and the sugar-free morphine solution, preferred the sugar-free morphine by 65% to 35%. Plus the ants’ brains showed elevated levels of dopamine, just as addicted mammals do. The authors were said to suggest that ants might make a good model for studying addiction in humans. Durk wonders why 35% of the ants DIDN’T choose morphine … Sandy suggests that maybe those ants had a different version of the D2 dopamine receptor.

HIGH IMPULSIVITY PREDICTS THE SWITCH TO COMPULSIVE COCAINE-TAKING

Rats, like humans, can get addicted to drugs. When rats are exposed to cocaine, 15-20% of them become addicted, which is similar to that observed in humans (Belin, 2008).

“… the essential feature of addiction … [is] … the persistence of drug-seeking in the face of negative consequences …” explain researchers in a 2008 paper (Belin, 2008). In their study, they found that high impulsivity “predicts the development of addiction-like behavior in rats … [and they note that, in humans,] … there is a high comorbidity between drug addiction and disorders characterized by impulsive behavior, such as attention deficit-hyperactivity disorder.”

Low serotonin levels are thought to be a cause of impulsivity. For example, reducing serotonin levels by tryptophan-restricted diets results in more impulsive choices in experiments. A recent paper (Bevilacqua, 2010) found that a mutation in the serotonin 2B receptor predisposed a Finnish population to severe impulsivity.

Lithium may reduce impulsivity, but studies reporting this association have involved doses much higher than the low-dose form that we use. One such study (in rats) found that a “moderate” dose of lithium (20 mg/kg) suppressed impulsive behavior (Ohmura, 2012). Research involving the low concentrations of lithium found in mineral waters and in some tap water has reported reduced impulsiveness and suicide in people.

Another way to reduce impulsivity is to take tryptophan (precursor to serotonin). See above in “Eating: Delay Discounting.”
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