1998 Nobel Prize for Discovery of Arginine’s role in creating Nitric Oxide

The Nobel Prize in Physiology or Medicine in 1998 recognized the health benefits of nitric oxide. Arginine, an amino acid that helps the body create nitric oxide, is one of the key ingredients in Muscle Memory™, a Designer Food® created by Durk Pearson and Sandy Shaw, who were among the first scientists to recommend that taking arginine supplements could help achieve a variety of life-extending benefits. Muscle Memory™ has been a life enhancement classic for more than a decade which enhances the body’s ability to form nitric oxide and helps support muscle and heart health.

 

Subject: Nobel Prize for Arginine and Nitric oxide discovery–https://www.nobelprize.org/prizes/medicine/1998/press-release/

Nitric oxide protects the heart, stimulates the brain, kills bacteria, etc.

It was a sensation that this simple, common air pollutant, which is formed when nitrogen burns, for instance in automobile exhaust fumes, could exert important functions in the organism. It was particularly surprising since NO is totally different from any other known signal molecule and so unstable that it is converted to nitrate and nitrite within 10 seconds. NO was known to be produced in bacteria but this simple molecule was not expected to be important in higher animals such as mammals.

Further research results rapidly confirmed that NO is a signal molecule of key importance for the cardiovascular system and it was also found to exert a series of other functions. We know today that NO acts as a signal molecule in the nervous system, as a weapon against infections, as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO is present in most living creatures and made by many different types of cells.

– When NO is produced by the innermost cell layer of the arteries, the endothelium, it rapidly spreads through the cell membranes to the underlying muscle cells. Their contraction is turned off by NO, resulting in a dilatation of the arteries. In this way, NO controls the blood pressure and its distribution. It also prevents the formation of thrombi.

– When NO is formed in nerve cells, it spreads rapidly in all directions, activating all cells in the vicinity. This can modulate many functions, from behaviour to gastrointestinal motility.

– When NO is produced in white blood cells (such as macrophages), huge quantities are achieved and become toxic to invading bacteria and parasites.

Importance in medicine today and tomorrow

Heart: In atherosclerosis, the endothelium has a reduced capacity to produce NO. However, NO can be furnished by treatment with nitroglycerin. Large efforts in drug discovery are currently aimed at generating more powerful and selective cardiac drugs based on the new knowledge of NO as a signal molecule.

Shock: Bacterial infections can lead to sepsis and circulatory shock. In this situation, NO plays a harmful role. White blood cells react to bacterial products by releasing enormous amounts of NO that dilate the blood vessels. The blood pressure drops and the patient may become unconscious. In this situation, inhibitors of NO synthesis may be useful in intensive care treatment.

Lungs: Intensive care patients can be treated by inhalation of NO gas. This has provided good results and even saved lives. For instance, NO gas has been used to reduce dangerously high blood pressure in the lungs of infants. But the dosage is critical since the gas can be toxic at high concentrations.

Cancer: White blood cells use NO not only to kill infectious agents such as bacteria, fungi and parasites, but also to defend the host against tumours. Scientists are currently testing whether NO can be used to stop the growth of tumours since this gas can induce programmed cell death, apoptosis.

Impotence: NO can initiate erection of the penis by dilating the blood vessels to the erectile bodies. This knowledge has already led to the development of new drugs against impotence.

Diagnostic analyses: Inflammatory diseases can be revealed by analysing the production of NO from e.g. lungs and intestines. This is used for diagnosing asthma, colitis, and other diseases.

NO is important for the olfactory sense and our capacity to recognise different scents. It may even be important for our memory.

Nitroglycerin

Alfred Nobel invented dynamite, a product in which the explosion-prone nitroglycerin is curbed by being absorbed in kieselguhr, a porous soil rich in shells of diatoms. When Nobel was taken ill with heart disease, his doctor prescribed nitroglycerin. Nobel refused to take it, knowing that it caused headache and ruling out that it could eliminate chest pain. In a letter, Nobel wrote: It is ironical that I am now ordered by my physician to eat nitroglycerin. It has been known since last century that the explosive, nitroglycerin, has beneficial effects against chest pain. However, it would take 100 years until it was clarified that nitroglycerin acts by releasing NO gas.

For more information about Muscle Memory™ and its benefits visit www.lifepriority.com or call 800-787-5438 — 8 am-11 pm, CST (M-F).

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.

*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.

*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

LE NEWS: The Power of Arginine

The Power of Arginine
DURK PEARSON & SANDY SHAW’S®
LIFE EXTENSION NEWSLETTERTM
©1988-1991

Life Extension Newsletter, written by Life Extension scientists Pearson & Shaw, was prescient with regard to many of the biomedical ideas it first brought to the attention of the public. Unfortunately, it is no longer available and thus, with the permission of the authors, we reproduce selected portions for your enlightenment. Please note the return of another Pearson & Shaw Newsletter, Life Extension News, the current issue of which is contained in this publication. The growth hormone story picks up where Sandy breaks her leg at a gerontological conference where she is initially attended to by no less than Dr. Denham Harman, M.D., Ph.D., father of the Free Radical Theory of Aging.

ISSUE #25
ARGININE RELEASES GROWTH HORMONE
Having a broken foot is extremely inconvenient and sometimes dangerous. Just try going up or down stairs on crutches! We had been about to start arginine supplementation experiments on ourselves for immunostimulation, when Sandy’s broken foot provided us with a golden opportunity. We had read scientific reports of arginine stimulating the healing of broken bones in experimental animals, and Sandy decided to take it.

Other nutrients have been shown to cause growth hormone release, including niacin (200 mg is a mild GH releaser) (Irie, 1967,1970), tyrosine (nutrient amino acid – releases a small amount of GH in a small percentage of subjects with 40 gram intravenous doses), and methionine (nutrient amino acid – releases GH but can cause atherosclerosis under certain conditions). The nutrient amino acid arginine and ornithine (another amino acid) are both relatively strong GH releasers. Arginine and ornithine can release enough GH to equal that found in a heavily exercising teenager.At this time, Sandy was 35 years old, and far over the hill in terms of exercise-induced GH release. She took 10 grams of arginine a day in a single dose on an empty stomach. (One might be able to ingest that amount daily in a very high protein diet heavy in chicken or turkey. Sandy was also taking about 2 grams of choline and 2 grams of vitamin B5 per day.) About 45 minutes to one hour after taking the arginine, Sandy did bench presses for about 3 minutes, once daily, on her back, so there was no stress on the broken foot. After six weeks on this regimen, she had lost about 25 pounds of fat and had put on about 5 pounds of muscle! We were amazed. We thought that amount of arginine might be enough to stimulate the release of growth hormone. We knew that growth hormone increased the ratio of muscle to fat. (Christy, 1979; Murad, 1980) But we didn’t realize how dramatic the effect could be in an essentially sedentary middle-aged research scientist. Arnold Schwarzenegger in his Bodybuilding for Men said that putting on 5 pounds of muscle would be difficult for an adult man working out every day for a year!

Arginine and ornithine cause growth hormone release via your brain’s cholinergic nervous system. (Casanueva, 1984) This is the system that uses acetylcholine – made in the brain from the nutrient choline with the help of the cofactor vitamin B5 – to transmit information between the nerve cells. Without adequate amounts of acetylcholine, neither arginine nor ornithine can cause growth hormone release, though we know of no evidence that choline or vitamin B5 alone can cause GH release. This is why we recommend the use of a choline + B5 supplement in conjunction with arginine or ornithine GH releasers. Note that many antihistamines, cold pills, and the non prescription sedative diphenhydramine are anticholinergics. These drugs will block the GH releasing effects of arginine and ornithine.

Contrary to what some people believe (and some fraudulent products claim), you can’t develop winning muscle mass without exercise, even if you take a growth hormone releaser like arginine. But arginine is very effective at helping you maintain muscle mass you already have, even if you are not exercising. We are two 47 year-old research scientists and almost completely sedentary, but we regularly take arginine supplements, as described below, and maintain the well muscled bodies we had twenty years ago. You may have seen 5’3″ Sandy bend steel horseshoes on television.

In 1982, after we reported our ideas and experiences regarding the use of growth hormone releasers such as arginine in our first book, Life Extension, A Practical Scientific Approach, there was a world-wide shortage of arginine for several months, and a world-wide shortage of ornithine for about a year! Their main prior use had been as ingredients in culture media.

ARGININE SUPPLEMENTATION
We personally use arginine in either one of two different ways: we take 12-24 grams 45 minutes to one hour before exercise (to enhance the effects of the exercise) or just before bedtime (to enhance both sex and the natural pulse of growth hormone release shortly after one falls asleep). We generally recommend the following total daily quantities of arginine (free base) for healthy male adults: Weight 100 to 140 pounds, 12 grams; 140 to 200 pounds, 18 grams; over 200 pounds, 24 grams. For healthy female non-pregnant, non-lactating adults: under 120 pounds, 6 grams; 120 to 180 pounds, 12 grams; over 180 pounds, 18 grams. Women are usually more sensitive to the GH releasing effects of arginine and ornithine than men. (Merimee, 1969) Start with about 25% of your target quantity, and increase it gradually over a period of a few days to minimize the occurrence of minor side effects such as nausea. If you prefer ornithine, use half of these amounts. The dose figures given in the literature usually refer to the amount of amino acid free base used, such as arginine. Many commercial products contain an acid addition salt such as arginine hydrochloride rather than the free base arginine. Some of the product labels give the amount of the contents as the free base, other as the hydrochloride. Unless the amount of the amino acid is given as the free base (eg, 6 grams arginine), you will need to take about 20% more since the hydrochloride adds about 20% to the weight without contributing to the GH releasing activity.

Don’t assume that more is always better. It is unlikely that a 60 gram dose would cause significantly more GH release that a 24 gram dose. A 30 gram injection of arginine is used to test pituitary function: this dose has been chosen to be high enough to completely saturate this GH release mechanism. (See the Cautions at the end of this article for side effects and precautions.)

It is important not to ingest certain other amino acids, either as a supplement or in foods, at the same time or shortly before taking the arginine. Some of these other amino acids, including lysine, compete with arginine to enter the brain (where the action takes place). You can take your protein supplement or high protein low glycemic index carbohydrate meal after your workout.

Casanueva, Villanueva, Cabranes, Cabezas-Cerrato, Fernandez-Cruz, “Cholinergic Mediation of Growth Hormone Secretion Elicited by Arginine, Clonidine, and Physical Exercise In Man,” J. Clin. Endocr. Metab.59(3):526-530 (1984)
Christy, “Anterior Pituitary Function in Normal Subjects and in Patients with Systemic Diseases,” in Obese, et al, editors Cecil Textbook of Medicine, 15th ed, pp.2085-2091, Philadelphia:Saunders (1979)
Irie, et al, “Effect of Nicotinic Acid Administration on Plasma Growth Hormone Concentrations,” Proc Soc Exptl Biol Med 126:708 (1967)
Merimee, et al, “Arginine Initiated Release of Growth Hormone: Factors Modifying the Response in Normal Men,” New Eng J Med. 280(26) :1434-1435 (1969)
Murad and Haynes, “Adenohypophyseal Hormones and Related Substances,” in Gilman, Goodman, Gilman editors Goodman and Gilman’s Pharmacological Basis of Therapeutics 6th ed, pp.1369-1396, New York:MacMillan (1980)

ISSUE #25 PAGE 7
CAUTION
Arginine Side Effects: Most men and some women report increased libido with arginine supplements. There may also be increased irritability. A large release of GH can also cause nausea. Remember how Arnold Schwarzenegger used to keep a barf bucket next to his workout station when he was a teen-ager? He said that if he wasn’t working out hard enough to throw up, he wasn’t working out hard enough to win. In his twenties, this no longer happened because the exercise no longer caused such a big GH release. You are less likely to have annoying side effects if you start out with a small amount, and gradually increase your dose over a period of couple of weeks.

Ornitine Side Effects: Arginine, but not ornithine is found in ordinary food protein. Arginine has been given to medically monitored subjects at up to 60 grams per day without reports of serious problems. Much less is known about the safety of the regular use of large amounts of ornithine. Since about half of the arginine that you ingest is normally converted to ornithine in your body, it isn’t surprising that the reported side effects of ornithine are similar to those of arginine. It takes about half as much ornithine as arginine to release a given amount of GH, but ornithine costs twice as much. We generally use arginine, considering it to be more medically conservative. The immunostimulant and wound healing stimulant effects of arginine are far better established, too. Moreover, arginine but not ornithine, increases sperm count.

Choline Side Effects: Too much choline and/or vitamin B5 can cause the production of too much acetylcholine. Since acetylcholine is what makes your muscles contract, this can cause excessive muscle tone. The most common symptoms or cholinergic excess is a stiff neck, a tension headache, or gut cramps, diarrhea, or constipation. You are less likely to have annoying side effects if you start out with a small amount, and gradually increase your dose over a period of a couple of weeks. Do not use choline bitartrate; in effective doses, there is so much bitartrate in this form of choline that diarrhea is almost inevitable. Chronic diarrhea isn’t just annoying; potassium loss can be so large that it may cause heart failure by ventricular fibrillation.

Niacin Side Effects: 200 milligrams of niacin will most certainly cause transitory skin flushing and a sensation or heat, burning, or itching, though this is not dangerous. Do not take more than 800 milligrams of niacin per day without medical supervision, since the livers of some individuals cannot tolerate higher doses.

Although the growth hormone releasing effects or arginine and ornithine have been stressed in this article, we do not wish to imply that all of the anabolic, wound healing, and immunostimulant effects of arginine and ornithine are due to their GH releasing activity. Arginine and ornithine also act as precursors to polyamines such as spermine and spermidine, which are growth stimulating substances, and these two amino acids have many other uses within the body, too. Nevertheless, the anabolic, wound healing, and immunostimulant effects of growth hormone itself are so similar to those of arginine and ornithine that we did not think that an exploration of this distinction would be of much interest to body builders and athletes.

ISSUE #13 PAGE 3
STIMULATION OF THE IMMUNE SYSTEM AND OF HEALING BY ARGININE
We have previously written about immune system stimulation and increased healing rate in experimental animals and humans with oral arginine supplements. Now a new clinical study reports the benefits of large (25 g) supplements of arginine in a liquid diet for postoperative recovery of major abdominal surgery for cancer.

The purpose of the study was to try to reduce the immunosuppression and catabolic response (loss of lean body tissue) that normally occurs after such a trauma. Glycine (43 g/day) was administered to other patients (who did not receive arginine) as a test of its possible utility. Although many animal studies have demonstrated the efficacy of arginine, relatively few human studies had been done. Barbul, in his excellent review, reports some of these. (For example, Dr. Barbul administered oral arginine hydrochloride (30 g/day) for one week and noted a significant increase in peripheral blood mean lymphocyte blastogenic response to con A and PHA, measures of immune system activity.)

The mean total daily caloric intake in this experiment was not significantly different between the arginine and glycine supplemented groups. However, daily nitrogen balance became positive after day 5 in the arginine group (indicating that lean body tissue was being built up faster than it was being broken down), whereas it remained negative in the glycine group throughout the seven day study period. There were increases in immune system T-lymphocyte activation in the arginine group and a slight increase in the glycine group, the difference between the two groups being significant. Only the arginine group had an increase in the CD4 (T helper cell) activity. (T helper cells are needed to help your immune system recognize and react to infections and cancer cells. AIDS patients fall prey to many infections because the AIDS virus kills the T helper cells.) Growth hormone increased in both groups, but somatomedin C (which mediates the effects of growth hormone) was significantly increased only in the arginine group on day 7.

Daly, et al, “Immune and Metabolic Effects of Arginine in the Surgical Patient,” Ann. Surg. Vol. 208(4), pp. 512 523 (1988)

ISSUE #23 PAGE 93
ARGININE-DERIVED NITRIC OXIDE AND ITS EFFECTS
An entirely new and important effect of the amino acid arginine has recently been discovered.

In 1987, scientists suggested that endothelium-derived relaxing factor (EDRF), a substance with important functions in the vascular (circulatory) system, such as blood pressure regulation, was nitric oxide, a gas. Now, a mere two years later, a lot more is known about nitric oxide, with evidence indicating that it is about nitric oxide, with evidence indicating that it is EDRF and that it is derived from the amino acid L-arginine. A two-day symposium was just held at the Royal Society in London entitled “Nitric Oxide from L-Arginine.”

Nitric oxide (NO) has now been found to also participate in regulation of the nervous and immune systems and is produced from arginine by the liver, adrenal, and kidney. The biological roles include control of vascular resistance and of platelet function. NO can mediate a profound vasorelaxation (reducing blood pressure) and inhibit both platelet adhesion (stickiness) and aggregation (clumping) which can lead to coronary thrombosis heart attacks and occlusive strokes. It has been hypothesized that some cardiovascular disease patients do not manufacture adequate amounts of NO. A lack of NO may play a role in vasospasm, which can lead to hypoxic tissue damage, just as occurs in a coronary or an occlusive stoke. Basal NO release is central to control of blood pressure and flow. High doses of an analog-antagonist of arginine called L-NMMA causes acute hypertension which is rapidly reversed by intravenous L-arginine. Endothelium derived relaxation is impaired by atherosclerosis and inhibited by LDL. LDL, when oxidized, is an even more effective inhibitor, which depresses NO production by endothelial cells. We would like to see a double-blind placebo controlled trial of arginine and antioxidant nutrient supplements for the control of hypertension and to inhibit abnormal clot formation.

Macrophage mediated killing of tumor cells and of some bacteria seems to involve NO. Some of the effects of L-arginine on immune functions, including increased thymic lymphopoiesis (increased T-cell production), stimulation of lymphocyte proliferation, interleukin production, promotion of tumor and graft refection and of wound healing, may involve NO derived from the arginine. Both animal experiments and double-blind placebo controlled trials in humans have shown that arginine supplements are immunostimulants and wound healing accelerators.

Griffith, Randall, “Nitric Oxide Comes of Age,” The Lancet pp. 875-876, Oct. 7, 1989
Palmer, Ashton, Moncada, Nature 333: 664-666 (1988)
Feigl, “EDRF – A Protective Factor?” letter to Nature 331: 11 Feb. 1988
Jacobs, “L-Arginine is Endogenous Source Of NO,” Trends in Pharmacological Sciences, Sept. 1988
Collier and Vallance, “Second Messenger Role for NO Widens to Nervous and Immune Systems,” Trends in Pharmacological Sciences, Nov. 1989

ISSUE, #26 PAGE 13
L-ARGININE REDUCES BLOOD PRESSURE IN HUMANS
In issue #23 [above] we wrote about a newly-discovered natural function of arginine: it serves as the precursor to NO, nitric oxide, a gas which is now believed to be endothelium-derived relaxing factor (EDRF) that powerfully relaxes blood vessels. Doctors at the Keio University School of Medicine in Tokyo recently tested the effects on human blood pressure of an infusion of L-arginine. They administered a dose of 500 mg/kg over 30 minutes (that is quite a lot, for example, the dose would be 35 grams for a 154 pound man) to five healthy men aged 24 to 37 and to five patients (four male) with essential hypertension aged 30 to 65. The antihypertensive drugs the latter patients were taking were withdrawn 4-7 days before the experiment.

The infusion caused rapid onset of hypotension in both groups, reducing both systolic and diastolic blood pressure. Blood pressure returned to baseline levels by 20 minutes following the infusion. The researchers thought the effects were probably caused by EDRF induced vasodilation.

In animal studies, L-arginine alone has not caused hypotension, although it has reversed the pressure (blood pressure increasing) effects of NG-monomethyl-L-arginine, a competitive inhibitor of EDRF synthetase (the enzyme that converts L-arginine to NO).

We would like to see a double-blind placebo controlled study of 12-18 grams of oral L-arginine (a common growth hormone releaser dose) on blood pressure. A lower dose taken orally would deliver less L-arginine than would be delivered over a longer period of time.

Nakaki, et al, “L-Arginine-Induced Hypotension,” The Lancet pg. 696, Sep. 15, 1990

ISSUE #26 PAGE 12
ARGININE AND SEX
We have found some very interesting information on arginine that suggests a mechanism for sexual enhancement (our own observations and those of others) reported anecdotally by both men and women using an arginine formulation.

On pp. 93-94 of issue #23, we discussed endothelium-derived relaxing factor (EDRF), a substance that relaxes blood vessels, and, thus, is important in the regulation of blood pressure (it has other functions, too, such as inhibiting platelet adhesion and aggregation which can lead to blood clots, occlusive strokes, and coronary thrombosis). It was recently discovered that EDRF is NO, nitric oxide, a gas, and that NO is produced from arginine by the liver, adrenal, and kidney.

Penile erection results when smooth muscle of the corpus cavernosum relaxes, which is followed by venous occlusion and engorgement of the corporal sinusoids (cavities) with blood. Four scientists now report that stimulation-induced relaxation of corporal smooth muscle is markedly inhibited by an inhibitor (NG-nitro-L-arginine) of the biosynthesis of NO from arginine, as well as by other agents that interfere with the biological actions of NO. Thus, penile erection may be mediated by NO. The chart included with their report shows that addition of L-arginine to rabbit corpus cavernosum preparations containing NG-nitro-L-arginine alone.

We have also had reports of increases in libido in women who take arginine. Although women do not have penile erection during sex, there is blood engorgement of homologous tissues: perhaps this is mediated by NO.

Ignarro, Bush, Buga, Rajfer, Nature (scientific correspondence), pp. 131-132 (13 Sept. 1990)

ISSUE #22 PAGE 84
POSSIBLE IMPROVED FERTILITY WITH ARGININE
Arginine Supplements Increase Sperm Count and Sperm Motility in Men With Low Sperm Counts/Motility

L-arginine enhanced sperm motility in vitro, with response to arginine following a dose-response curve (more L-arginine causing greater motility). Other substances tested that did not enhance sperm motility included L-ornithine, d-arginine, L-lysine, and the arginine analogs L-homoarginine and L-nitroarginine.

A daily dose of 4 grams of L-arginine was used to treat 178 men with sterility because of oligospermia (low sperm count). Sperm count increased by 100% in 42 cases (23.6%) and 15 pregnancies occurred soon after in this group. In 69 patients (38.7%), there was a marked increase in the number and motility of sperm and 13 pregnancies resulted. In 21 cases (12.3%) a moderate increase occurred in sperm count (but it was still classified as oligospermic) and in half sperm motility improved. In 46 patients (25.4%), there was no improvement in either sperm count or motility: these patients had severe oligospermia. The authors note that in some studies arginine treatment of oligospermic patients was unsuccessful probably, they propose, because of insufficient doses (1 to 2 grams daily). Other studies they cite reported significant improvement in more than 30% of patients given larger doses (10 to 20 grams daily).

Schachter, Goldman, Zukerman, “Treatment of Oligospermia with the Amino Acid Arginine,” The Journal of Urology 110:311 (1973)

Re-post permission Durk Pearson and Sandy Shaw to Life Priority Inc.

Live Long and Prosper – Durk Pearson and Sandy Shaw

 

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.
*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.
*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

 

Greg Pryor – September 2018 Men’s Health!

“A logical way to slow up my aging process is to keep my body and brain more fit through the use of a few essential supplements.”

September Celebrates of Men’s Health!

In today’s fast-paced lifestyles, most men are faced with increasing mental and physical demands as they age. Personally, I have found that an easy, logical way to slow up my aging process is to keep my body and brain more fit through the use of a few essential supplements with each meal.

I urge all men to consider, at least, the use of the following supplements:

  •  Lifeguard-a high-quality multivitamin created to try and help to provide immune support and fill in the gaps of your diet,
  •  Omega-3 Priority™-a potent omega-3 supplement for heart (EPA) and brain health (DHA),
  • Prostate Priority™ specific nutrients that may help promote a healthy prostate,
  •  Joint Decision™ or Total Joint Complexglucosamine that may help to support and maintain healthy cartilage health.

I feel that the consistent, daily use of the right nutrients in supplement form (and in adequate amounts!) is one of the most important health decisions that we can make. Based on the past 20 years of being in the dietary supplement industry through my company, Life Priority, and my 16 year career as a pro athlete, I feel strongly that using high-quality supplements is imperative. Your diet is most likely lacking in one or more essential nutrients. You can help yourself feel better and slow up your personal aging process by using high-quality supplements.

In addition, men are at increased risk for heart related issues including heart attack and cardiovascular disease. They are also at a higher risk for prostate cancer. Both heart disease and prostate cancer affect millions of men every year and take many away from their families and friends too soon. If men can incorporate more exercise, consume more fish with essential fatty acids (EFA’s), visit their doctors regularly and watch out for depression and high blood pressure, stop smoking and use a daily multivitamin, they can increase their life expectancy and live healthier, fuller lives.

I have been involved as a retail customer or a marketer of dietary supplements since 1991.  Don’t leave your physical and mental well-being up to anyone else! It’s your life! Your body, including your brain, is aging each day and you can give yourself a better chance at living a healthier (and happier!) life by simply using enough of the right nutrients each day with meals or at bedtime.

I helped form Life Priority, Inc. in 1994 to secure the nutritional products I wanted for my own personal use.  A major reason that Life Priority was formed was because of the research of 2 scientists who were the co-authors of a NY Times best-seller Life Extension, A Practical Scientific Approach, which was written specifically for doctors. The authors, Durk Pearson and Sandy Shaw, wrote Life Extension so that doctors could understand how using certain nutrients in adequate amounts could slow up the aging process.

To Your Health!

Greg Pryor-Life Priority President, Co-Founder and  #1 Customer

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.

*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem
*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

Testimonial: Taking Life Priority products have changed my Life! Harry H.

Testimonial from Harry H. Life Priority customer since 1998!

I’ve been a truck driver for almost 30 years and a Life Priority customer for over 15 years.

I use to spend the first part of my mornings feeling like I was running behind the curve, like I was trying to catch up with my day. Then I discovered Life Priority. Now, I start each morning with a combination drink that includes Lift, Mind and Muscle Memory.

Quite honestly, it has changed my life. I find that my mornings are now more focused and I am ready to take on the day. It’s amazing how greatLife Priority Lift Powder it feels to start the day feeling good, feeling focused, and feeling in charge. I make another drink in the afternoon to keep me feeling that way the rest of the day.

I also take several other Life Priority supplements. I take them with confidence knowing that Greg and Michelle have
researched them and will only offer them if they are quality products.

When it comes to Life Priority supplements…I’m a BELIEVER!!!!

Harry J. H. Shawnee, KS.

Mental Fitness is a Life Priority!

Mental Fitness is a Life Priority!

As we age and encounter multiple stressors and responsibilities, our minds become pulled countless directions and we can see the negative effects. Sometimes we forget things, can’t focus or be as sharp as we once were and this can hurt our daily lives. To overcome these deficiencies, we reach for caffeine or other artificial sources in an attempt to regain our former mental capacities, but things like caffeine don’t solve the problem. Artificial boosters can only keep you “up” for so long before you come crashing back down, and they have other harmful side effects. So instead of providing your mind and body with a temporary solution, chooses to help correct the whole problem and create a healthier you.

Life Priority has paired with scientists Durk Pearson & Sandy Shaw® and their expertise since 1994 to establish a line of supplements specifically designed to help improve and develop your brain and all of its cognitive faculties. These products were created after countless hours of research and testing. We only use the safest and highest quality ingredients based on Durk and Sandy’s recommendations. With so much care directed toward providing a quality product, our supplements are designed to deliver real results.

Lift and Lift Caps were created to help provide you with some energy when you’re feeling like you’re on empty. Lift™ is great because it’s the natural way to help increase energy. It helps stimulate your mind and your body using your own faculties so you don’t experience a caffeine crash later. In addition to helping with your energy and focus, Lift™ can also help curb your appetite and thus help you lose weight. Two other great products are Mind™ and Muscle Memory™.  They can help improve your memory, concentration and physical ability to function. All of these supplements can help you create a healthier mind and body for the future, instead of just for a few hours or a day.

 

Too often in today’s world, people look for the quick fix. Our lives are filled with so many responsibilities and obstacles that finding solutions to problems instead of masking them is challenging. Caffeine and energy drinks can only do so much or so long, and they can lead to negative side effects in some cases like weight gain. Instead of reaching for these quick fixes, make the decision to create a healthier you with a healthier lifestyle using natural supplements. With Life Priority, your health is our only concern and our line of carefully tested products is designed to help suit your needs and help you become healthier.

To Your Mental Health!

Life Priority Inc. www.lifepriority.com 800-787-5438

Information for educational purposes only. Not intended to diagnose, treat or cure any medical condition.

Do you need Omega-3 Priority™?

Omega-3 Priority™

Supports Cardiovascular Function-Circulatory System*- and Brain Health.

Questions and Answers:
Q: What is Omega-3 Priority™?
A: Life Priority’s Omega-3 Priority™ is a pharmaceutical grade fish oil concentrate providing one of the highest potencies of EPA 400/mg (eicosapentaenoic acid) and DHA 200/mg (docosahexaenoic acid) available*.

Q: Where do people get omega-3 in their diet?
A: The best sources are from deep water fish. (Flax seed and/or flax oil (ALA) are not the optimum source of EPA and DHA.)

Q: Are omega-3 fatty acids essential for optimum health?
A: Polyunsaturated fatty acids, specifically from omega-3 fatty acids, play an essential role in the function and health of cell membranes.

Q: What are the specific benefits from using omega-3 fatty acids?
A: Research shows that omega-3 fatty acids reduce inflammation and may help lower risk of chronic diseases such as heart disease, cancer, and arthritis. Omega-3 fatty acids are highly concentrated in the brain and appear to be important for cognitive (brain memory and performance) and behavioral function.*

Q: Are there any side effects?
A: Because of blood thinning activity, those who are on NSAIDS, warfarin, or other anti-clotting medications should consult a physician/pharmacist before using*.

Q: How much omega-3 fatty acid should I take each day?
A: Depending on the amount of fresh, deep sea fish that you eat daily, you should be fine using 1-2 capsules of Omega 3 Priority™ per day after meals. If you do not eat deep sea fish, you might consider using 3 to 4 capsules per day after meals.

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.

Life Priority Inc. 11184 Antioch RD #417 Overland Park, KS 66213                                                                        Phone: 800-787-5438  913-438-5433   www.lifepriority.com
Information provided for educational purposes only. *These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.

 

Happy Father’s Day! –4 tips to Be a Healthy Coach

Happy Father’s Day! –4 tips to Be a Healthy Coach:  TAKE YOUR SUPPLEMENTS!

I have been a advocate for vitamins and supplements since I started my professional baseball career in 1971 with the Washington Senators. I worked hard and tried to improve my health with a good diet, working out and using supplements. In 1991, I learned that the use of the right dietary supplements is one of the most important decisions that a person will make each day.  So take a seat on the bench and consider the 4 simple tips below.

Tip #1—Use Lifeguard -high-Quality Multi-Vitamin, Multi-Mineral With Each Meal

Your body needs nutrients 24 hours a day so using supplements after each meal is very logical. Most of the food we eat is devoid of virtually all the trace minerals we need for survival so  consider using a high-potency multi-vitamin with each meal to help provide free radical protection and to build up the immune system.  There was a time when it took a lot of arguing to convince people that they needed some kind of vitamin/mineral supplement. Not so anymore. Although people may not know the exact numbers, they are aware that the food that is sold in markets today is less nutritious than it was 50 years ago

Tip #2—Use the Omega-3 “Essential” Nutrient,.

One of the major building blocks of the brain, the omega-3 fatty acid docosahexaenoic acid (DHA) is critical for optimal brain health and function at all ages of life.  Getting enough DHA from the diet is impractical and the easiest way to consume it is from fish oil. Omega 3 is one of the most researched and added value supplements due to the value it provides for brain and cardiac health. Make getting a high quality Omega-3 a top priority.

Tip #3—Specific Nutrients for Joint Health

I have been using glucosamine HCl since 1996 to keep my cartilage healthy.  I was introduced to the value of glucosamine by a former employee of Mr. Ewing Kauffman, founder of Marion Labs and former owner of the KC Royals. Since ’96, my company, Life Priority has enjoyed helping thousands of people understand how using a high-quality form of glucosamine can help support and maintain healthy joints. Using glucosamine has allowed me to play golf with less joint pain and also participate in the KC Royals Fantasy Camp each year.

 

Tip #4—Specific Nutrients for Maintaining a Healthy Prostate

Prostate health becomes more important with age, particularly for men over the age of 40. It’s worthwhile considering this issue far in advance. There are certain nutrients that can help the health of the prostate including, lycopene, saw palmetto, pygeum, vitamin C, vitamin D-3 and zinc..

I feel that the use of  quality supplements in the right dosages at the right times can help you live a healthier life and slow up the aging process. To receive many more free nutritional tips, email me at customerservice@lifepriority.com.  To Your Health, Greg Pryor

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.
*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.
*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

Baseball is the Lord’s Game!

Casey and the Lord stood by to observe a baseball game. The Lord’s team was playing Satan’s team. The Lord’s team was at bat, the score was tied zero to zero, and it was the bottom of the 9th inning with two outs:

THE LORD’S BASEBALL GAME

Casey and the Lord stood by to observe a baseball game. The Lord’s team was playing Satan’s team. The Lord’s team was at bat, the score was tied zero to zero, and it was the bottom of the 9th inning with two outs:

They continued to watch as a batter stepped up to the plate named ‘Love.’

Love swung at the first pitch and hit a single, because ‘Love never fails.’

The next batter was named Faith, who also got a single because Faith works with Love.

The next batter up was named Godly Wisdom. Satan wound up and threw the first

pitch. Godly Wisdom looked it over and let it pass: Ball one. Three more pitches

and Godly Wisdom walked because he never swings at what Satan throws.

The bases were now loaded. The Lord then turned to Casey and told him He

was now going to bring in His star player. Up to the plate stepped Grace.

Casey said, ‘He sure doesn’t look like much!’

Satan’s whole team relaxed when they saw Grace.

Thinking he had won the game, Satan wound up and fired his first pitch. To the shock

of everyone, Grace hit the ball harder than anyone had ever seen! But Satan was not

worried, his center fielder let very few get by. The center fielder went up for the ball, but it went right through his glove, hit him on the head and sent him crashing on the ground; and the roaring crowds went wild as the ball continued over the fence.

The Lord’s team won!

The Lord then asked Casey if he knew why Love, Faith and Godly Wisdom

could get on base but couldn’t win the game. Casey answered that he didn’t know

The Lord explained, ‘If your love, faith and wisdom had won the game, you

would think you had done it by yourself. Love, Faith and Wisdom will get you on

base but only My Grace can get you Home.

‘For by Grace are you saved, it is a gift of God; not of works, lest any man should

boast.’ Ephesians 2:8-9

‘For the Lord God is a sun and shield; the Lord will give grace and glory; no good thing will He withhold from those who walk uprightly.’ Psalm 84:11

A Poem of Inspiration Author Unknown

Thank you to Women and Mothers Everywhere

May is the special month we honor the women who have made a difference in our lives.

We at Life Priority would like to honor all women by showing you ways to rev up your health regimen. Your loved ones will thank you in return. . . because you will feel a renewed sense of well-being and confidence in knowing how you can easily improve your health. And we all know that when the special women in our lives feel good everyone feels good.

Home is where the heart is.

Did you know that heart disease is the leading cause of death of American women each year, killing 1 in 4, and 5 times as many women as breast cancer?

Up until a woman enters menopause, the female hormone estrogen offers protection against heart disease by maintaining levels of high-density lipoprotein (HDL) cholesterol. Estrogen also helps to relax the smooth muscle of the arteries, which supports healthy blood pressure. These benefits disappear after menopause, which is why the risk for heart disease rises in women later than in men. But women of all ages should be concerned about maintaining a healthy heart.

Additionally, since a woman’s heart, arteries and other blood vessels are smaller than a man’s it takes less plaque to fill them up. Women also tend to have blockages in the smaller arteries that supply blood to the heart, not just in the main arteries.

10 ways to support a healthy heart:

1. Eat a nutritious, high-fiber, low-fat heart healthy diet
2. Include foods high in phytonutrients (the nutrients found in plants)
3. Get plenty of foods containing omega-3 fatty acids (cold water fish) or take Life Priority’s Omega-3 Priority. Vegetarians should take flax seed oil or ground flax seed.
4. Practice a stress reduction technique, such as yoga or meditation
5. Exercise
6. Stop smoking!
7. Reduce and/or avoid alcohol
8. Get an annual physical exam to rule out other health factor risks
9. Drink 6 to 8 glasses of purified water every day
10. Get plenty of restful sleep!

But that’s not all! Now is the time to start taking important heart-healthy supplements.

1. CoQ10 (also known as Coenzyme Q10 and ubiquinone) is a co-enzyme and antioxidant found in the mitochondria of every cell and in high concentrations in heart tissue. It helps maintain cardiovascular health and promotes vitality and energy. Co-Q10 is directly involved in creating 95% of the body’s usable energy. It can increase the pumping strength of an aging heart through increased energy production, which in turn enhances the amount of blood flowing through the heart and out to the body.

When you are young and healthy, your liver can produce adequate amounts of Co-Q10. But as you get older, your liver struggles to detoxify the chemicals in your food and environment. Over time, your ability to maintain efficacious amounts of Co-Q10 is severely compromised, which can dramatically impact your health. While CoQ10 production levels peak around age 20, they can decline to an average of just 68% of peak production by age 40. By age 80, CoQ10 levels can drop to 43% of normal, healthy levels–which is why it is important to add CoQ10 to your health regimen!

2. Omega-3 Essential fatty acids (EFAs) are the healthy fats you cannot live without. They are critical to every cell in your body and essential for normal growth, functioning and anti-aging. Since the body cannot manufacture them, EFAs must come from the food you eat and/or nutritional supplements. Most Americans eat plenty of saturated fats, but few eat the fats that you need to support healthy blood pressure and a healthy heart.

It’s a fact of life. Maintaining balance in the female physiology is complex … because women’s hormones are in a constant state of flux, waxing and waning like the moon. The balance becomes even more delicate when the body begins to decrease its estrogen production. Whether you need ongoing or transitional support, you’ll be amazed by how much easier it is to fight stress and fatigue and bring your system back into balance with Omega-3s. Life Priority’s Omega-3 Priority helps support mood, memory, blood lipid levels, and cardiovascular health. This product is really a no-brainer for all women, no matter how old they are.

Calcium and magnesium supplementation — along with exercise and a healthy diet —is the best way to support healthy bones.

3. Calcium is the most abundant mineral in your body and plays a vital role in many areas of health including the maintenance of proper nerve and muscle function, normal blood clotting, cardiovascular function, proper sleep, and bone formation. 99% of the body’s calcium is found in your bones, which serves two functions: it provides strength and structure and it serves as a calcium bank or reserve. Whenever your body senses a decrease in blood calcium, calcium is removed from the bones. This is why it’s absolutely vital to maintain your calcium intake on a daily basis, so that calcium is not drawn out of your bones setting up the stage for osteoporosis.

Preventing osteoporosis:
One out of two women older than age 50 suffers an osteoporosis-related fracture during her lifetime. Complications from these fractures are a major killer of women. Recent research shows that osteoporosis is not limited to post-menopausal women. Each year men suffer one third of all the hip fractures that occur, and one third of these men will not survive more than a year. Fortunately, research has also shown that a healthy diet, weight-bearing exercise and calcium supplementation can aid the body in building and maintaining healthy bone mass, while reducing the risk of osteoporosis.

4. Magnesium is necessary for every major biological process including the body’s production of healthy bone. Magnesium helps the body absorb calcium, converts vitamin D into its active form for calcium absorption and helps regulate calcium.

Often called the “relaxation” mineral, magnesium assists in helping you sleep through the night peacefully without leg cramps, spasms heart palpitations, or anxiety. In fact, if you experience twitching or cramping of any kind, you probably have a magnesium deficiency. Magnesium is found in nuts, seeds, legumes, green leafy vegetables, whole grains and avocados. Taking Magnesium Priority is a great way to ensure that you are getting the adequate daily allowance of this vital mineral.

Try this recipe for a delicious and nutritious start to the day:

Blueberry and Yogurt Pancakes (serves 3)

½ cup flour (your choice, i.e. all-purpose, whole wheat, non-gluten)
1 tsp sugar
1 tsp baking powder
¼ tsp baking soda
¼ tsp salt
¾ cup milk
1 Tbsp. butter
½ cup plain Greek yogurt
1 egg
½ cup blueberries
¼ cup walnut pieces
Oil or butter for frying pan

Combine the dry ingredients. Whisk together the egg, milk and yogurt and 1 Tbsp. of melted butter. Blend with the dry ingredients and then gently add ¼ cup of the blueberries. Heat frying pan and add oil. When sizzling hot, drop batter to form pancakes. Sprinkle more blueberries onto each pancake and let the pancakes cook until the edges start to brown and you see bubbles appear.

Serve with more fresh blueberries, if desired, and chopped walnuts.

This delicious recipe provides calcium, magnesium, vitamin D, antioxidants, and protein, and omega-3 fatty acids (in the walnuts).

Enjoy!

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.

*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.

*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

A Mother’s Love: The Driving Force Behind Life Priority

Testimonies by Paige, Storey, and Hailey Pryor, daughters of Life Priority owner, Michelle Pryor

“The month of May has grown sweeter to me, not because I’ve become a Mother myself, but because I’ve watched my Mother become a Grandmother.  I just wish she were with me everyday to remind my kids to take their vitamins.  I attribute my Mother for instilling the knowledge of supplementation and healthy living in me.  My parents’ passion for health and helping people makes me so proud and they talk about their customers as our own family.  Thank you for supporting Life Priority and our family.” – Paige Cook, Michelle’s 1st born

“My mom is one of the most selfless, passionate, nurturing, loving women on the planet – which is certainly why she is the rock of the Pryor family, and it goes without saying, the driving force behind Life Priority. I feel tremendously blessed that my parents created this company to provide the world’s finest health and wellness supplements. My Mom lives and breathes every single product, and is determined to share this incredible company with the world. Thank you for your commitment to your health, and supporting Life Priority over the few decades. There is so much heart and soul in this company, and we are proud you’re a part of our family!” – Storey Pryor, Favorite Daughter

“Most people who cross paths with Michelle Pryor (my mother) are quick to understand the raw and genuine nature of her spirit. I am so grateful to have been raised by a mother with unwavering moral and ethical beliefs. I cannot think of a truer inspiration to have been raised by. Over the years I’ve been fortunate enough to adopt some of her most redeeming qualities. You will hear her say, “your health is your most valuable asset” – which I cannot agree with more. I am so thankful that her interest in health and vitamins trickled down into us (her daughters). She truly does care about the well being of others, including all our loyal and valuable customers.” – Hailey Pryor, the baby