Arginine and Muscle Memory- The “Fountain of Youth?” (Interview with Life Extension Scientists: Durk Pearson & Sandy Shaw)

Life Extension Book A

Life Priority Presents— Durk Pearson and Sandy Shaw’s   MUSCLE MEMORY

Dear Customer:

One of the most valuable products offered by Life   Priority, Muscle Memory, has been described as “Youth in a Bottle”   by the formulators, Durk Pearson and Sandy Shaw. When you use it consistently   before workouts or at bedtime (on an empty stomach), you will experience why   this could be your personal fountain of youth.

The enclosed interview will describe the value of using   Muscle Memory. In 1991, I began using this formula to increase my strength   and endurance, speed up my recovery time, and have less soreness after   exercise. The use of Muscle Memory allows you to get the most from your   exercise.

For optimum results, use 1-3 servings of Muscle Memory 1   hour before exercise on an empty stomach (avoid eating protein 2-3 hours   before work outs) or 1 hour before bedtime. Read label instructions before   using Muscle Memory.

Here’s to the Retention of the Youth that is still in   you!

Greg Pryor, President Life Priority

____________________________________________________________________

Interview on Muscle Memory with scientists   Durk Pearson and Sandy Shaw–

Greg: Durk and Sandy, our customers   want to know about the Muscle Memory. Would you explain the formula to our customers   and the reasons why you created it? What is growth hormone and how important   is it to keep our bodies supplied with nutrients that increase the release of   growth hormone?

Durk: Sure Greg, our interest in growth   hormone and it’s history goes back a long, long way, to the early ’70s, when   we realized that not everything associated with aging was necessarily caused   by free radicals and that corrective treatments could go beyond controlling   free radicals. Sandy and I became concerned about changes in the neuroendocrine   system that occurred with aging. For example, as a woman gets older, one of   the obvious changes is menopause. In males, there is a reduction in   testosterone. Some of these changes are in response to internal   “clocks”; others may be due to random damage, possibly related to   free radicals, possibly related to something else, such as receptor loss or   down-regulation. One of the most striking changes we noticed was the loss of   immune system function with age. A person at age 70 is lucky to have 20% of   their T-cell function left compared with when they were a young adult. That’s   why pneumonia used to be called “the old man’s friend.” That is,   pneumonia would kill you over a period of a few days; whereas something like   cancer would kill you over a period of a year, much more miserably.

Sandy: A case of viral pneumonia might   not even stop an otherwise healthy young person from going to work- just make   them miserable for a while- and certainly would never put them in the   hospital. The same virus could easily kill somebody in their 70’s.

Durk: We also noted that as you get   older you start putting on more and more body fat and it becomes harder and   harder to put on lean body mass. A potentially disastrous occurrence is the   fact that it takes longer and longer for wounds to heal. A wound that would   have healed in 5 weeks when you were in your teens or early 20’s might not   heal for 5 months when you’re in your 70’s.

Sandy: What we figured out is that all of   these changes were consistent with a reduction in the release of human growth   hormone.

Durk: Growth hormone (GH) doesn’t make   a person grow any taller after they’ve gone through puberty. You just don’t   grow any taller after that. However, during our mid-20’s to 30 or so, there’s   a big drop in GH output. And that’s when a person begins to find it much more   difficult to put on lean body mass by exercising. For example, if a person in   their teens or early 20’s does heavy exercise, they will release a relatively   large amount of GH from their pituitary. Or if they’re injured, they’ll also   release GH. By the time they’re in their 40’s, it takes a heck of an injury   to get a good GH release, and exercise will rarely do it anymore.

Sandy: It is possible to improve the   response of the GH-releasing system through the use of nutrients, and that’s   something that we became interested in during the 1970’s.

Durk: About 1976 we came to the   conclusion that it was quite possible that a reduction in GH was responsible   for many of the problems of aging, and we got a private grant to do   literature research on this. In fact, the private granting foundation asked   the person who won the Nobel Prize for sequencing human growth hormone   whether he thought our idea had any merit. He said, “Yes, this sounds   interesting. Let’s hope they follow up on it.”

So, as we proceeded to read more about   it, the more interesting it looked. Our thoughts turned to how you get GH   released, because actual human GH was very difficult to come by. Since then,   recombinant human GH has made the hormone much more available, although it’s   still very expensive.

Sandy: So what we did then was to look for   various substances that would cause release of endogenous GH, and we found   out that there were quite a few. For example, some of the opiates will do it,   but for obvious reasons that wasn’t really a suitable source.

Durk: We found out that there were   certain drugs that would do it, for example, L-dopa. But it’s highly   experimental for those who don’t have Parkinson’s disease to take L-dopa   every day for the rest of their lives. What we finally found is that amino   acids release GH, and some do it much better than others. In particular,   different amino acids had different ratios of insulin release to GH release.   Our goal was to find one that would maximize GH release and minimize insulin   release. Arginine and ornithine both fit that criterion.

We decided to use arginine for two   reasons. (Although ornithine was twice as powerful as arginine on a   gram-for-gram basis, it costs twice as much.) The first reason was that you   have a minute amount of ornithine in your diet, whereas you have substantial   amounts of arginine.

Sandy: Ornithine isn’t used to make   proteins.

Durk: You make proteins that contain   arginine. And as a result, we thought the choice of arginine would be more   conservative with respect to what human metabolism is adapted to. Also, we   found out that 20 grams of arginine is normally used intravenously as a   provocative test for GH release to see if a person’s pituitary is responding   normally. We wanted to find out whether oral doses were also capable of doing   that.

It turned out that oral arginine was   particularly effective at releasing GH when you add a couple of additional   factors to it, choline and vitamin B5 (pantothenate). That’s because GH   release involves the cholinergic nervous system.

Arginine along with choline and B5   works just fine when taken orally as long as you don’t have a lot of other   proteins in your stomach breaking down into amino acids that compete with   arginine’s entry into the brain. It worked even better than we had expected.

Sandy was the first experimental subject   matter for this treatment. We were at a Gordon research conference on the   biology of aging back in 1979. And Sandy   jumped up to try to get something off a shelf in our room, and when she came   back down she didn’t come down on her foot straight and there was this   horrible cracking sound.

Sandy: I noticed that my foot was swelling   up, and it was very tender and I couldn’t walk on it very well. I had to   hobble around.

Durk: In fact, it was Dr. Denham   Harman, the father of the free-radical theory of aging, who diagnosed her as   having a probable broken foot and suggested she get it X-rayed.

Sandy: Which I did, and it was broken. We   were aware of studies on animals with broken bones that healed faster with an   arginine supplement. And so we thought, “Well, we’ve done enough   literature search on this; time to start taking it.” The arginine growth   hormone release should help to speed up the healing.

Durk: Because she wasn’t moving around   nearly as much, she thought she ought to do some exercise, so she did some   bench presses lying on her back, which didn’t put any load on her foot. I   knew how much weight she was lifting, and I measured how far she lifted it   and counted the number of times she did it- she spent about 3 minutes a day   on it- and, by golly, in 5 weeks she lost about 20 pounds of fat and put on   about 5 pounds of lean body mass. Arnold Schwarzenegger in “The   Education of a Bodybuilder” said it would be difficult for a dedicated   male bodybuilder to accomplish that much gain in a year.

Also, the foot seemed to be completely   healed up a lot sooner than we expected. The doctor said it would be 2 or 3   months before she was really able to walk around on it. Yet in 5 weeks she   felt fine, had it X-rayed, and it was okay. I mean, it wasn’t broken anymore;   not only that, in the X-ray it didn’t look like it had ever been broken.

Another very interesting story involves   a friend of ours, a plump, sedentary, gourmet, 72 years old, who fell down on   an icy sidewalk several years ago and broke his arm. This guy is very   sedentary. His idea of exercise is taking the elevator from his condominium   down to the underground parking garage, underneath his law office and taking   the elevator up to his office.

His doctor told him that in about 5   months he would probably have to do bone grafts because he didn’t think it   would heal, given our friend’s age and condition. Well, our friend called us   up and said “Didn’t you once tell me something about accelerated wound   healing?” He asked the doctor about that and the doctor was very   dogmatic. “No, it’s not possible to speed up wound healing, there’s   nothing that can be done about it.” So he called us back and we told him   about Muscle Memory our formulation of arginine, choline, and B5, and sent   him some samples. He started taking three servings when he went to bed at   night. Five weeks later he felt so good, he went back to the doctor and said,   “I want you to take the cast off.” The doctor got a real snicker out   of that.

Sandy: He thought it was simply ridiculous.   But the patient asked for it, so he took another X-ray.

Durk: The doctor was absolutely   dumbfounded when he looked at the X-ray. It looked as though the bone had   never been broken, there was not shadow on it indicating a fracture and the   bone was a full density.

If a 12 year-old breaks an arm, you can   take the cast off at 5 weeks. But if you X-ray it, the bone is not going to   be at full density. Here, you have a guy who’s 72 years old with full density   at 5 weeks! In fact, the doctor said that if he hadn’t personally taken the   original X-ray, personally taken the second X-ray, and personally set that   arm and put it in a cast, he’d call it some type of insurance scam, because   what he saw was “completely impossible.”

We’ve heard of this sort of thing   happening to a lot of people using our arginine, choline and B5 combination,   like bodybuilders and Olympic athletes and so forth, who have also found out   how useful this is. It really helps a lot in maintaining the ability to gain   strength from peak output exercise. It also seems to help improve skin   elasticity. A lot of people who’ve been taking it for a year or so notice   that their skin, particularly on their face and neck, stays nice and tight.   And that’s because GH causes the liver to release IGF-1, which in turn   up-regulates production of elastin in the skin and also, I might add, in the   arteries. Elastin’s the molecule that makes tissue all nice and springy and   elastic. Anybody who has seen the skin pinch test done on the back of my own   hands can see that it’s really much more elastic than you would expect for   someone who’s 54 years old. We’ve been taking this formulation since 1979 now   -18 years – which is a pretty significant fraction of our adult lifetimes.

Durk: Remember, there are various   things that can limit your life span and also your quality of life. One thing   is simply muscular strength. A lot of elderly people end up falling down,   breaking their hips and then dying within the next year, because they never   really recover. Such falls have been traced in some cases to the loss of   equilibrium due to damage to the inner ear. But in most cases it’s thought to   be due to lack of muscular strength. A person who stumbles can usually right   himself but if you don’t have enough muscular strength, down you go. This   seems to be a major problem. The average woman over 65, I believe, cannot   lift 10 pounds.

Sandy: That’s right. It’s pretty shocking.

Durk: When you consider that a gallon   just of milk weighs about 9 pounds, you realize what a big limitation that   is. Another thing GH does is help maintain the function of T-cells in the   immune system. The heart of that is the thymus, where T-cells are produced,   selected, and educated or programmed. Maintaining GH levels can help retain   thymus function and thymus mass.

Maintaining elasticity goes beyond the   production of elastin. One very important thing about arginine is that it is   a very powerful sacrificial target for cross-linkers. If nothing else gets   you, you’re going to end up having to go on kidney dialysis at the age of 90   or 100 or 120, because, throughout your lifetime, cross-linking reactions are   taking place in the collagen in the basement membrane of your kidneys.

Sandy: As a result of glycosylation, this   causes the kidney’s basement membranes to thicken throughout life, and   eventually it becomes thick enough that it is not filtering the serum well at   all. In people who have diabetes, the process is accelerated. Diabetics   usually die of kidney failure. There was a very exciting study in diabetic   mice that were given arginine to what would be – scaled up to a human dose –   about 3 gm of arginine a day. They found that the mice that received the   arginine had normal kidneys when they became old as compared with controls.   The diabetic mice that did not receive arginine were dying of kidney failure.   They had thickened basement membranes in their kidneys.

Durk: In fact, what they found was that   there was no increase in thickness after about 6 months in the basement   membranes of those mice that got the arginine. It entirely abolished that   age-related increase in basement membrane thickness and cross-linkage.

Sandy: It’s interesting to note, too, that   the tests also have a basement membrane that thickens throughout life.

Durk: In some cases GH can block the   effects of insulin. And a person who has type II diabetes is already insulin   resistant. You don’t want to make them anymore insulin resistant. In fact, we   have found that in a small percentage of type II diabetics, the blood sugar   will go sky high if they take Muscle Memory. With most others, that doesn’t   happen. In fact, gradually increasing the doses of Muscle Memory may result   in an increased insulin sensitivity and a decrease in blood sugar levels.   However, this is something that has to be done under a doctor’s supervision,   where they’re actually measuring your blood sugar response as you go from   perhaps half of one serving of the nutrients to start and gradually work your   way up.

Sandy: That’s why we recommend on the label   that diabetics not use the product.

Durk: Let me also mention another   precaution: Arginine can increase the rate of growth of all tissues and that   includes, potentially, cancerous tissues. If cancer already exists, it might   accelerate its growth.

Sandy: I was reading in one paper about   breast cancer and GH. The authors found an improvement in the immune response   to the tumor in those patients taking GH, but, at the same time, the tumor   was getting assistance in growing, because growth factors – any growth   factors – do exactly that: improve growth.

Durk: Right. If a person has cancer,   they do not want to take this. If they’ve had cancer, and their doctor says,   “We got it all, there’s none left,” then there’s no reason that   they shouldn’t be able to take it.

Sandy: But caution is always the byword. I   think that by now your customers know that the two of us are extremely   conservative. We try to take as few risks as we possibly can and hope that   will contribute to our being able to live a very long time.

Durk: Another interesting thing I’ve   discovered: I’m pretty doggone sedentary; I spend most of my time lying on my   waterbed or a lounge chair reading scientific journals. But sometimes I go   out and do some very vigorous things like digging post holes or carting   concrete sacks around or branding cattle or digging out a hot spring. Believe   me, shoveling mud is a very, very backbreaking task. I find that if I don’t   take Muscle Memory before I do that, I will have aches and pains starting the   next day that’ll be really bad and will last several days.

Sandy: How achy were you after the cattle   branding?

Durk: Not at all because I was sopping   up Muscle Memory all day; over the day I took about three servings of Muscle   Memory spread out over the day. I just mixed it up in a drink and put it in   the cooler.

Durk: For GH release, you need to take   it all at once: two servings for a woman or three for a man, preferably at   bedtime, because about an hour and a half after you go to sleep is your   biggest GH release if you’re past, say, your mid 20’s. Or, alternatively,   about 3/4 of an hour before you engage in heavy peak-output exercise. But in   the cases of branding or digging out a hot spring, I’m usually at it all day   long. So I take about three servings, put it in some ice water, and stick it   in the cooler. I usually mix it with a couple of servings of Lift as well. I   just drink that throughout the day. No aches and pains that day. No aches and   pains the next day or the day after.

Durk: Basically what you want is to   mimic, as far as possible, the natural pulsatile release. What you don’t want   to do is to have elevated levels of GH all the time.

Sandy: Which is what you get with GH   infusions or even subcutaneous injections of GH that they’re giving elderly   people. These are not like the physiological releases of growth hormone.

Durk: GH is supposed to be released in   pulses, like insulin, and a continuous high level results in a resistance to   GH and all sorts of problems downstream from that. Now when you’re sipping   three servings over a period of maybe 6 hours of heavy work throughout the   day, you’re not going to get any GH release effect, but you will get the   beneficial effects of the arginine-derived nitric oxide.

Sandy: There have been a number of studies   of arginine with respect to atherosclerosis, particularly in animal models   like rabbits. The first sign you see before you see any fatty streaks or any   other visible evidence of atherosclerosis is that the arteries fail to dilate   in response to acetylcholine. That can be reversed by infusing arginine.

Durk: Instantly reversed! Twenty   seconds after you bathe the rabbits artery with the arginine, you’ve reversed   that resistance and normalized the response of the arteries so they dilate.

We know of one case where that happened   in a human. Our 72-year-old friend, after his arm healed up so fast, called   up and said, “Would it hurt me to continue taking this stuff? It really   makes me feel good, and it sure healed me up. I think this is doing a lot of good   for me.” He wasn’t a diabetic, so we said, “Well, we’ve been taking   it for 10 years now, go right ahead and do it.”

Sandy: So he started doing that. About a   year and a half later, he had a fast-synchronized MRI scan of his brain,   which gives very fine pictures of the cerebral arteries. He said that the   doctor that did this, a different doctor from the one who fixed his arm, was   absolutely astounded because, of his three major cerebral arteries, two of   them were completely clear, and one of them had about a 20% obstruction,   which is about the bottom end of the ability of this technique to measure at   that time. The doctor asked him what sort of diet he was on – was he a   vegetarian? Was he on a Pritikin diet, or what? And he said, “Well, my   diet was bacon and eggs every breakfast.” And that’s just about true;   those are the sort of things he eats. He’d be better off if he ate a lot more   veggies, but that isn’t what he eats.

Sandy: We don’t know what his arteries   looked like before he started using the arginine supplement, but the end   result is certainly consistent with what the experimental studies have shown   with arginine.

Arginine has also been studied for its   effects on blood pressure. Part of the blood pressure regulation process is   the arteries being able to dilate under the control of the cholinergic   nervous system.

Durk: And this is mediated by nitric   oxide. The scientist who figured that out won the Nobel Prize for it.

Sandy: A lot of people who have high blood   pressure, especially associated with atherosclerosis, have a failure of their   nitric oxide artery dilation system, and arginine often can help reverse   that.

Durk: We’ve been told that, under a   physician’s supervision, some people have been able to reduce their doses of   anti-hypertensive medication by taking Muscle Memory throughout the day. Some   people have even been able to discontinue the drugs entirely, particularly if   they add potassium and magnesium along with an arginine, choline and B5   supplement throughout the day. But this should be done only under a   physician’s supervision.

Sandy: One other thing to keep in mind is   that using nutrients to get GH release is a very different thing from using   the hormone itself, from the point of view of the feedback controls that   regulate the release of hormones in the pituitary and elsewhere. When you   take growth hormone itself, you bypass the normal regulatory features that   control when the hormone is released and how much is released. You put GH in   there, and you just override those controls. When you take arginine and   choline and B5, you still have all of those regulatory mechanisms in place to   control how much is released and when its released.

Durk: Another thing that we definitely   don’t want to forget is that the mechanism that causes erections in male   mammals is, in fact, nitric oxide. That’s what causes the vasodilation that   results in the corpus cavernosa engorgement with blood producing an erection.   If you take Muscle Memory 30-45 minutes before sex, you’re likely to notice   the difference. There’s similar erectile tissue in women inside the lining of   the vagina.

Sandy: Just like the arteries that we talked   about earlier in the development of artherosclerosis, the cholinergic   mechanisms are also involved in the dilation of the blood vessels to the penis.

Durk: I’m not at all surprised that   occurs.

Durk: I think that Muscle Memory does a   lot to make your neuroendocrine system look younger. In fact, the mixture was   used in a double-blind, placebo-controlled study at a private fertility   clinic. They took women who were not ovulating and put them on pergodile,   which is a dopaminergic agonist, FDA-approved for fertility purposes (as well   as for treating Parkinson’s patients). Most of them ovulated after they’d   been on Pergodile for a while. The ones that had failed to ovulate after 6   months were put on two servings of the arginine-choline-B5 mixture at bedtime   every night in addition to Pergodile.

The doctor said that the results were   absolutely amazing: 80% of the women ovulated within days of going on the   mixture. He said it was like turning on a light switch. I might add that one   woman was about 1 and a half years postmenopausal; another one was about 2   and a half years postmenopausal. So, in a lot of ways, Muscle Memory makes   your endocrine system look like that of a younger person.

Durk: Yes, in fact, it can. We reported   that over a decade ago in one of our Life Extension books. A few hundred   milligrams of buffered niacin can indeed do that; that’s what I take at   bedtime along with my Muscle Memory. About 200 mg of niacin will give you   double or triple the GH level compared with backgrounds. This is significant,   but it’s nowhere near as big a pulse as you would likely get with the   arginine-choline-B5 in Muscle Memory.

Durk: You would typically get one   several times as big as with the niacin alone.

Durk: I use it myself whenever I have   to learn some sort of new motor type-task. Also, we have had some interesting   comments from various people. We know a retired professional golfer in his   sixties who, over a period of about 5 weeks, took five strokes off his game.   Normally at his age – he’d been playing at least a few times a week for 20   years – you’re not going to get better; you’re just going to get worse with   the passage of time. And that’s what he said; his game had gradually been   getting worse over the years. Taking five strokes off in 5 weeks is not   something that normally happens. But it’s been found that nitric oxide   release is absolutely essential for motor learning in the cerebellum, and it   also appears to be necessary for long-term potentiation in the brain, which   is the mechanism that’s involved in long-term memory. And I think that   explains his success.

Durk: When you go over it all, it   really sounds like too much of a panacea to be real. As the years have gone   on we’ve found more and more delightful things about arginine.

Durk: I’ll tell you this; if you’re   full of anabolic steroids to the point where you’ve down-regulated your   anabolic steroid receptors, the dietary supplement might conceivably not   work. Another possibility is that people who abuse GH by injecting it,   subcutaneously or intramuscularly, are definitely going to develop resistance   to it because it’s not being given in the pulsatile manner. Moreover the   doses of many GH releasers are inadequate, and most formulations lack   adequate choline and B5.

Sandy: Another thing is that, people who are   restricting their calorie intake significantly are going to be less likely to   release growth hormone because, under the conditions of fasting or caloric   restriction, animals go into a state where they do not grow. They reserve the   energy that they’re getting for more important things, like maintenance.   Growth is not a priority when you’re getting a restricted amount of energy   intake. So, for people who are on a diet that’s low enough, they may not get   a growth hormone release.

Durk: Also, if a person takes a big   slug of protein supplement, like 50 gm of protein, along with their Muscle   Memory, not much of that arginine is going to get to the brain compared with   taking it on an empty stomach. I’m afraid that a lot of body-builders may be   taking a protein supplement along with Muscle Memory before exercising. What   they should do is take the Muscle Memory before the exercise and take the   protein afterwards.

Muscle MemoryTM was designed by Life Extension scientists Durk Pearson   & Sandy Shaw for their own use.

Durk Pearson and Sandy Shaw were among the first scientists, beginning more   that 15 years ago, to recommend that people take arginine supplements
(along with choline and B-5) to boost their natural GH release and thereby   achieve a variety of life-extending benefits, including building lean muscle   mass
(in preference to fat), accelerating wound healing, strengthening bones,   improving immunity, and enhancing skin flexibility.

Muscle MemoryTM has been a Life Priority classic since 1994, for more   than a decade for:

  • People who recognize that the ingredients in        Muscle MemoryTM help accelerate physical fitness.
  • Those interested in the role of nutrition in        biological aging.       Muscle MemoryTM helps trigger your own internal biochemical        resources of mental and physical power for enhanced vitality and        youthfulness.
  • Store in a cool, dry, dark place.

SUGGESTED USE: Read the directions on the bottle   before consuming.
Use 1-3 tablespoons 45 minutes before work-outs (on an empty   stomach) or take 1-3 tablespoons of 1 hour before bedtime.

Order Muscle MemoryTM now!

 

http://www.lifepriority.com.

© Copyright LIFE PRIORITY

Life Priority, established in 1994, offers supplements that are scientifically-formulated, results-oriented, and GRAS (Generally Recognized As Safe) and are manufactured at USDA and FDA inspected facilities.
*The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.
*Any testimonials on this web site are based on individual results and do not constitute a guarantee that you will achieve the same results.

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